研究兴趣海洋特殊环境微生物资源、化学及功能研究。
代表性成果简介主要从事海洋特殊环境微生物资源、化学及功能方面的研究工作,取得了一系列创新性研究成果,包括分离鉴定100多个新化合物,发现具有生物活性的单体化合物40多个。近年来,先后主持国家基金项目2项,主持广东省-中科院全面战略合作项目(第二负责人)和国家863课题子课题各1项,参加973计划项目(担任项目办秘书)、国家基金重点项目、广东海洋经济创新发展区域示范等6项课题的研究;已在Org. Lett.、J. Nat. Prod.、Mar. Drugs等刊物发表论文53篇(含SCI收录论文40篇),参与出版专著1册,获授权发明专利3项;获广东省等科技成果奖2项;担任Journal of Agricultural and Food ChemistryMarine Drugs、Natural Product Research等杂志审稿人。指导和协助指导研究生6名。
工作经历2018.07-至今,中科院南海海洋所,人事教育处处长
2017.12-至今,中科院南海海洋所,研究员
2012.07-2018.07,中科院南海海洋所,人事教育处副处长
2010.12-2017.12,中科院南海海洋所,副研究员
2008.07-2010.12,中科院南海海洋所,助理研究员
2003.08-2005.07,中科院海洋所,研究助理
教育经历2005.09-2008.06,中国海洋大学,药物化学,博士
1996.09-2003.07,安徽农业大学,农学学士、硕士
获奖及荣誉1. 2011年度广东省科技发明一等奖(排名第十一)
2. 2007年度海洋创新成果二等奖(排名第十)
代表性成果论文发表(第一或通讯作者)
1. Zhong, W.-M.; Wang, J.-F.; Wei, X.-Y.; Zeng, Q.; Chen, X.-Y.; Xiang, Y.; Tian, X.-P.; Zhang, S.; Long, L.-J. *; Wang, F.-Z. *, (+)- and (?)-Eurotone A: A pair of enantiomeric polyketide dimers from a marine-derived fungus Eurotium sp. SCSIO F452. Tetrahedron Lett. 2019, 60 (24), 1600-1603.
2. Zhong, W. M.; Wang, J. F.; Wei, X. Y.; Fu, T. D.; Chen, Y. C.; Zeng, Q.; Huang, Z. H.; Huang, X. N.; Zhang, W. M.; Zhang, S.; Long, L. J. *; Wang, F. Z. *, Three Pairs of New Spirocyclic Alkaloid Enantiomers From the Marine-Derived Fungus Eurotium sp. SCSIO F452. Frontiers in Chemistry 2019, 7, 350.
3. Zeng, Q.; Zhong, W. M.; Chen, Y. C.; Xiang, Y.; Chen, X. Y.; Tian, X. P.; Zhang, W. M.; Zhang, S.; Wang, F. Z. *, A new butenolide derivative from the deep-sea fungus Aspergillus terreus SCSIO FZQ028. Nat Prod Res 2019, 1-8.
4. Zhong, W.; Wang, J.; Wei, X.; Chen, Y.; Fu, T.; Xiang, Y.; Huang, X.; Tian, X.; Xiao, Z.; Zhang, W.; Zhang, S.; Long, L*.; Wang, F.*, Variecolortins A-C, Three Pairs of Spirocyclic Diketopiperazine Enantiomers from the Marine-Derived Fungus Eurotium sp. SCSIO F452. Org. Lett. 2018, 20 (15), 4593-4596.
5. Zhong, W. M.; Wang, J. F.; Shi, X. F.; Wei, X. Y.; Chen, Y. C.; Zeng, Q.; Xiang, Y.; Chen, X. Y.; Tian, X. P.; Xiao, Z. H.; Zhang, W. M.; Wang, F. Z.*; Zhang, S.*, Eurotiumins A-E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp SCSIO F452. Marine Drugs 2018, 16 (4), 136.
6. Wang, F. Z.; Li R.; Long L.J.; Tian X.P.; Xiao Z.H.; Zhang S.; Yin H., A three-phase solvent system in high-speed counter-current chromatographic for the separation and purification of bioactive constituents from Acanthus ilicifolius. Chromatographia 2015, 78(21), 1401-1407
7. Wang, F. Z.; Huang,Z; Shi, X. F.; Chen, Y. C.; Zhang, W. M.; Tian, X. P.; Li, j.; Zhang, S., Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457, Bioorg. Med. Chem. Lett. 2012, 22 (23), 7265-7267.
8. Huang, H. B.; Wang, F. Z. (并列第一); Luo, M. H.; Chen, Y. H.; Song, Y. X.; Wang, B.; Ma, J. Y.; Zhang, W. M.; Zhang, C. S.; Zhang, S.; Ju, J. H., Halogenated Anthraquinones from the Marine-derived Fungus Aspergillus sp. SCSIO F063. J. Nat. Prod. 2012, 75 (7), 1346-1352.
9. Wang, F. Z.; Li, D. H.; Zhu, T. J.; Zhang, M.; Gu, Q. Q., Pseurotin A(1) and A(2), two new 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-diones from the holothurian-derived fungus Aspergillus fumigatus WFZ-25. Can. J. Chem., 2011, 89(1): 72-76.
10. Wang, F. Z.; Tian, X. P.; Huang, C. G.; Li, Q. X.; Zhang, S., Marinactinones A-C, new gamma-pyrones from marine actinomycete Marinactinospora thermotolerans SCSIO 00606. J. Antibiot. 2011, 64 (2), 189-192.
11. Wang, F. Z.; Wei, H. J.; Zhu, T. J.; Li, D. H.; Lin, Z. J.; Gu, Q. Q., Three New Cytochalasins from the Marine-Derived Fungus Spicaria elegans KLA03 by Supplementing the Cultures with L- and D-Tryptophan. Chem Biodivers 2011, 8 (5), 887-94.
12. Wang, F. Z.; Zhu, T. J.; Zhang, M.; Lin, A. Q.; Zhu, W. M.; Gu, Q. Q., Structural determination of aspericins A-C, new furan and pyran derivates from the marine-derived fungus Rhizopus sp 2-PDA-61, by 1D and 2D NMR spectroscopy. Magn. Reson. Chem. 2010, 48 (2), 155-158
13. Wang, F. Z.; Fang, Y. C.; Zhu, T. J.; Zhang, M.; Lin, A. Q.; Gu, Q. Q.; Zhu, W. M., Seven new prenylated indole diketopiperazine alkaloids from holothurian-derived fungus Aspergillus fumigatus. Tetrahedron 2008, 64(34), 7986-7991.
14. Wang, F.; Fang, Y.; Zhang, M.; Lin, A.; Zhu, A.; Gu, Q.; Zhu, W., Six new ergosterols from the marine-derived fungus Rhizopus sp. Steroids 2008, 73 (1), 19-26.
15. Wang, F. Z.; Zhang, M.; Sun, W.; Gu, Q. Q.; Zhu, W. M., 5a-hydroxy-9-methoxy-11-(3- methyl-2-butenyl)-12-(2-methyl-1-propenyl)-2, 3,11,12-tetrahydro-1H,5H-pyrrolo 1 '',2 '': 4 ',5 ' pyrazino 1 ',2 ': 1,6 pyrido 3,4-b indole-5,6,14(5aH, 14aH)-trione. Acta Crystallographica Section E-Structure Reports Online 2007, 63, O1859-O1860.
授权专利(第一发明人)
1. 王发左, 张偲, 黄智, 田新朋, 李洁. 含硫双吲哚二酮哌嗪类化合物及其在制备抗肿瘤药物中的应用. 公开号CN102911188B(2015.01.07),专利号:ZL201210301553.1